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Syd (Radha Mitchell), a low-level editor at a photography magazine eager to establish herself, discovers her neighbor is the once-celebrated downtown photographer Lucy Berliner (Ally Sheedy). Although Syd lives with her boyfriend (Gabriel Mann), she is drawn to Lucy, who has a volatile relationship with her heroin-addicted girlfriend, Greta (Patricia Clarkson). As Syd starts sleeping with Lucy, she is pulled into a glamorous but dangerous art-world scene, full of drugs and unexpected pleasures.